The aim of the project GENOMAeSALUTE is the creation of Genome Research Center for Health (CRGS) a strategic infrastructure for genomics translational research in Campania to fight cancers and to protect and improve human health. The project is co-financed by Campania Region within the Research and Innovation Strategies for Smart Specialization Program “the Campania Region fight against cancer” on the Notice "Implementation of Development Projects/Enhancement of the regional system of research infrastructures for the fight against oncological pathologies” (DD N.366 OF 10.23.2018. Total cost of the Project: € 10.000.000, Total duration: 47 months, starting date 05.30.2019).
The main mission of the Infrastructure is to expand knowledge on the structure and function of the human genome, including the genetic and epigenetic alterations that cause diseases and is aimed at identifying new therapeutic strategies, offering patients targeted therapies, taking into account their genes, of lifestyle and the environment. The infrastructure is a concentrate of innovative technologies and skills in which basic and translational research in Genomics and Informatics applied to Medicine and related fields are combined.
CRGS is a consortium company created for the management of IR and including all the project partners.
In this sense, the CRGS represents an example of integration of the Campania innovation ecosystem in the Life Sciences, for the involvement of Universities, SMEs and large industrial groups operating in Research and Development focused on developing genomics and translational informatics for health.
OUR MISSION
We aim to achieve our mission by:
- Using personalized genomic information aimed at developing disease biomarkers and innovative approaches for personalized and preventive medicine.
- Implementing innovative technologies for the diagnosis, treatment and support at cancer pathologies.
- Offering advanced research services in molecular medicine thanks to the availability of latest generation technologies and high technical-scientific expertise in Genomics, Bioinformatics and Computational Biology.
- Setting up and operating services and technological platforms for the research communities.
- Organizing and offering development and career opportunities to the next generation of scientists.
- Promoting technology transfer with industry, to foster the transformation of scientific discoveries into tangible applications.
- Disseminating scientific activities and achievements.
OUR VISION
The Genome Research Center for Health (CRGS) is an innovative center that combines basic and translational research in genomics and informatics applied to medicine and omics sciences.
Adhering to the "One Health" vision, the Center is ready to seize research opportunities also in the sectors of animal welfare and the plant world that have implications on human health and well-being.
The CRGS has significant technological capacity in the production of genomic data and computational potential for the analysis and storage of biomedical data, able to support large projects in genetics, genomics and precision medicine. The Center is empowered with technological capability for high-throughput genomic data generation and the computational potential for genomic and biomedical data analysis and storage, conceived to make possible large-and mid-scale genomics and precision medicine projects
The Center is open to scientific, technological and industrial collaborations in its fields of interest with the aim to be able to support the regional and national scientific and medical community.
HUB 1
Campus of Medicine of the University of Salerno (Baronissi, SA)
Hub 1 is located at the University of Salerno's campus in Baronissi, on the premises of the ‘Scuola Medica Salernitana’ Department of Medicine, Surgery and Dentistry.
The laboratories have a floor area of 800 m2, with 650 m2 housing specialised laboratories for oncology- and health protection-related research, and the other 150 m2 hosting the Data Center where the computing infrastructure (HPC) is located.
The personnel operating in the hub 1 on a continuous basis include researchers, faculty and technicians from the University of Salerno, GVM Care & Research, C.G. RUESCH and Genomix4Life.
HUB 2
Biogem (Ariano Irpino, AV)
Hub 2 is located on the BIOGEM Campus in Contrada Camporeale in Ariano Irpino. The gaol within the CRGS is to enable single cell-level multi-omics analysis (DNA-seq and RNA-seq), from samples and libraries preparation to sequencing and integrated bioinformatic analysis. This approach will make it possible to conduct innovative studies on single-cell cancer heterogeneity for several molecular levels.
Le attrezzature, specificamente del nodo 2 sono installate sia presso i Laboratori di Diagnostica Molecolare che presso il Server Center.
The personal operating in the hub 2 on a continuous basis include researchers, faculty and technicians from Biogem and from the University of Sannio.
HUB 3
University of Sannio (Benevento)
Hub 3 is located at the Battistine site of the University of Sannio in Via Port'Arsa 11 in the basement, where all the equipment is allocated.
The University of Sannio (Benevento), thanks to the experience gained by the Computational Biology group (www.bioinformatics-sannio.org), the BENEVENTO hub oversee performing integrative analysis of large datasets by linking genomic alterations to changes in methylation and transcription profiles. The scope is to identify driver alterations that affect cancer progression and therapy response.
The hub is therefore configured to be able to perform large-scale computational analyses in conjunction with a set of small laboratory equipment to validate the alterations.The personnel operating in the hub 3 on a continuous basis include researchers, faculty and technicians from Biogem and from the University of Sannio.
Translated with Linguana